Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar
نویسندگان
چکیده
منابع مشابه
Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis.
tabby and downless mutant mice have apparently identical defects in teeth, hair and sweat glands. Recently, genes responsible for these spontaneous mutations have been identified. downless (Dl) encodes Edar, a novel member of the tumour necrosis factor (TNF) receptor family, containing the characteristic extracellular cysteine rich fold, a single transmembrane region and a death homology domain...
متن کاملThe activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development.
Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth p...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2004
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.20138